Peripheral eosinophilia as the first manifestation of B-cell acute lymphoblastic leukemia with t(5;14)(q31;q32)

Pediatric B Cell Acute Lymphoblastic Leukemia presenting with Paraneoplastic Acute Disseminated Encephalomyelitis

Acute Disseminated Encephalomyelitis (ADEM) is a monophasic demyelinating disease most often triggered by infection or immunization, though associations with malignancy and stem cell transplant have been described. We described the case of a four-year-old boy with new-onset neurological symptoms associated with ADEM, acute leukemia, and equivocal evidence of Mycoplasma pneumoniae infection. He ...

acute hepatitis as a manifestation of acute lymphoblastic leukemia

Hyper-eosinophilia in granular acute B-cell lymphoblastic leukemia with myeloid antigen expression.

Acute lymphoblastic leukemia with eosinophilia (ALLEo) is a rare but a distinctive clinical entity. Clinical features of idiopathic hyper-eosinophilic syndrome (HES) can be seen in patients with ALLEo. We report a 10-year-old girl, in whom HES was initially suspected but further investigation confirmed the diagnosis of acute B-cell lymphoblastic leukemia with myeloid antigen expression. Clinica...

nephrotic syndrome as the first manifestation of acute myelogenous leukemia

the hematological malignancies associated with nephrotic syndrome are mainly hodgkin’s and non-hodgkin’s lymphomas and chronic lymphocytic leukemia. acute myelogenous leukemia (aml) has rarely been described in associated with nephritic syndrome. we report a rare case of acute myelogenous leukemia who presented with nephrotic syndrome. a previously healthy 62-year-old man was admitted in nephro...

Arthritis as presenting manifestation of acute lymphoblastic leukemia in children

Introduction At disease onset children with acute lymphoblastic leukemia (ALL) may present with arthralgia (join pain) or even signs of arthritis with joint swelling, redness, and restriction of motion. This might cause misdiagnosis and thereby lead to prolonged diagnostic delay. The present study aimed to identify ALL children with joint involvement and to compare their characteristics and out...